Karthika V.K. started her career as an editor at Penguin Books India, then moved to HarperCollins India, where she was publisher for ten years. She joined Westland Publications Ltd, an Amazon company, in January 2017, to build a list that prioritizes literary fiction and narrative non-fiction.
In the course of her twenty-year career, Karthika has edited and published books in different genres including fiction, non-fiction, translation, poetry and comics. The writers she has worked with include Booker-prize winner Aravind Adiga, Anita Nair, Anuja Chauhan, Rana Dasgupta, Shashi Deshpande, Arun Shourie, Manu Joseph, Mrinal Pande, Josy Joseph, Sarnath Banerjee, Amruta Patil, Paul Zachariah, Karthika Nair, Raghu Karnad, Rohini Mohan and Manu Pillai.